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We describe seven men with a neurologic disease clinically indistinguishable from multiple sclerosis occurring in association with seropositivity for the human immunodeficiency virus,type 1(HIV-1). Histopathology of the CNS obtained in three patients(2 by brain biopsy,1 at autopsy)was consistent with MS.The neurologic symptoms preceded the onset of clinically evident immunosuppression in all patients.In three men,HIV-1 seropositivity was demonstrated concomitantly or within 3 months of the onset of their neurologic disease.In the others,features of MS preceded the demonstration of HIV-1 seropositivity by 41 months,59 months, 11 years,and 18 years respectively.Despite the superimposition of varying degrees of cellular immunodeficiency associated with HIV-1 infection,six of these men continued to experience relapsing neurologic symptoms. |
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